‘Yes, that is certainly about right. I seek out a Actual physical understanding of biological units within a bottom-up way. I feel you could potentially distinguish 3 strains of study in my team in the intervening time. The very first worries chromosome composition: How can you get yourself a metre-very long DNA polymer folded and organised in this type of microscopic mobile? We have now designed visualisation procedures that permit us to review how, such as, SMC proteins loop DNA (movie on Youtube) to be able to Create up chromosomes.
Our team scientific tests bacterial mobile division and is also aiming to constitute a ‘base up biology’ in synthetic cells that will autonomously divide. Our key fascination lies in cell division, chromatin structure, and spatial control.
For a individual, I have the biblical assignment to discover and use anything in development for the benefit of my neighbour. I never expertise any conflict between faith and science. Quite the opposite, my faith stimulates me to carry out science, to get open up-minded on the planet.’
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, produced a whole new way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased flexibility
‘Initially we checked out Organic methods which has a Bodily check out and acted on the basis with the tools cees dekker we knew. It took a several years before we started off Operating far more on the massive Organic issues. I then began to simply call it nanobiology, a time period that did not exist at time.
Atomic force microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion
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Bulk-surface coupling identifies the mechanistic link involving Min-protein patterns in vivo and in vitro
‘The idea that There may be such a point for a commencing, a big bang, is presently an interesting signpost to look at that there was a creator. But additional usually, and on the basis of pure rationality, I also get there in a Christian interpretation of reality. An atheistic worldview is really a naturalistic worldview: essentially, you will find only atoms and all-natural forces that we can easily measure.
2006, 1st demonstration of molecular sorting in a lab on the chip working with biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic energy conversion within a nanofluidic channel
Visualization of unstained DNA nanostructures with Superior in-concentration transmission electron microscopy procedures
The biophysicist from Delft – who has long been One of the more cited experts while in the Netherlands For a long time – will take his responsibility to add into the rationalization and popularisation of his operate on the border of physics and biology exceptionally severely and on a regular basis appears while in the media; if not to take a look at his get the job done, then about the relationship in between science and his Christian religion.